Endocrine Abstracts

Epidermal growth factor (EGF) and heregulin (HRG) act via ErbB receptors, to stimulate Akt and ERK. These drive breast cancer cell proliferation and the network is targeted in cancer therapy (1). Single cell responses show marked cell-cell variation and information theory provides statistical measures that take the effect this noise has on information transfer into account (2). Here we quantify the mutual information (MI) between stimulus concentration and effects in MCF7 cell...

Glomerular podocytes are directly regulated by insulin (1) and podocyte insulin resistance is implicated in diabetic kidney disease. Information theory derived statistical measures can be used to quantify information transfer via cell signalling pathways (2). This novel approach takes into account cell-cell variation in responses and the impact that this noise has on information transfer but has not yet been applied to signalling in podocytes. Here we quantify the mutual infor...